How Does Complement Affect Hematological Malignancies: From Basic Mechanisms to Clinical Application

Complement, as a central immune surveillance system, can be activated within seconds upon stimulation, thereby displaying multiple immune effector functions. However, in pathologic scenarios (like in tumor progression), activated complement can both display protective effects to control tumor development and passively promotes the tumor growth. Clinical investigations show that patients with several hematological malignancies often display abnormal level of specific complement components, which in turn modulates complement activation or deregulated cascade. In the past decades, complement-dependent cytotoxicity and complement-dependent cell-mediated phagocytosis were fully approved to display vital roles in monoclonal antibody-based immunotherapies, especially in therapies against hematological malignancies. However, tumor-mediated complement evasion presents a big challenge for such a therapy. This review aims to provide an integrative overview on the roles of the complement in tumor promotion, highlights complement mediated effects on antibody-based immunotherapy against distinct hematological tumors, hopefully provides a theoretical basis for the development of complement-based cancer targeted therapies

Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity

Vascular smooth muscle cells (VSMCs) constitute the major cells in the media layer of arteries, and are critical to maintain the integrity of the arterial wall. They participate in arterial wall remodeling, and play important roles in atherosclerosis throughout all stages of the disease. Studies demonstrate that VSMCs can adopt numerous phenotypes depending on inputs from endothelial cells (ECs) of the intima, resident cells of the adventitia, circulating immune cells, hormones, and plasma lipoproteins. This plasticity allows them to perform multiple tasks in physiology and disease. In this minireview, we focus on a previously underappreciated activity of VSMCs, i.e., their impact on atherosclerosis immunity via formation of artery tertiary lymphoid organs (ATLOs)

Effects of Different Materials on the Tribological Performance of PVD TiN Films under Starved Lubrication Regime

Grit blasting is one simple but effective method to modify the morphology of material surface and can improve the tribological performance. In this study, a thick TiN film was prepared by arc ion plating on the steel disk treated with grit blasting, and the rough surface coated solid film was obtained. The tribological properties of solid film against different materials were evaluated under starved lubrication regime. The results showed that the friction coefficients of rough titanium nitride (TiN) films were lower than those of rough steel disks exclude alumina ball under starved lubrication, and the wear rates of TiN film were negligible due to the high hardness of TiN film and small contact area. For four kinds of balls including steel ball, silicon nitride, zirconia, and alumina, the wear scar diameter of steel ball is biggest, and the wear scar diameters of other balls are small. The hardness of steel ball is less than others, which results in the easy abrasion and increases the contact area to reduce the pressure. So the friction coefficient of TiN against steel is low and steady

Synthesis of Organic Dye-Impregnated Silica Shell-Coated Iron Oxide Nanoparticles by a New Method

A new method for preparing magnetic iron oxide nanoparticles coated by organic dye-doped silica shell was developed in this article. Iron oxide nanoparticles were first coated with dye-impregnated silica shell by the hydrolysis of hexadecyltrimethoxysilane (HTMOS) which produced a hydrophobic core for the entrapment of organic dye molecules. Then, the particles were coated with a hydrophilic shell by the hydrolysis of tetraethylorthosilicate (TEOS), which enabled water dispersal of the resulting nanoparticles. The final product was characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, photoluminescence spectroscopy, and vibration sample magnetometer. All the characterization results proved the final samples possessed magnetic and fluorescent properties simultaneously. And this new multifunctional nanomaterial possessed high photostability and minimal dye leakage

Interplanetary shock-associated aurora

Interplanetary shocks or solar wind pressure pulses have prompted impacts on Earth’s magnetospheric and ionospheric environment, especially in causing dynamic changes to the bright aurora in the polar ionosphere. The auroral phenomenon associated with shock impingements, referred to as shock aurora, exhibits distinct signatures differing from other geophysical features on the dayside polar ionosphere. Shock aurora provides a direct manifestation of the solar wind–magnetosphere–ionosphere interaction. Imagers onboard satellites can obtain the associated large-scale auroral characteristics during shock impingement on the magnetopause. Therefore, auroral data from satellites are very useful for surveying the comprehensive features of shock aurora and their general evolution. Nonetheless, the ground-based high temporal-spatial resolution all-sky imagers installed at scientific stations play an essential role in revealing medium- and small-scale characteristics of shock aurora. Here, we focus on shock aurora imaging signatures measured by imagers onboard satellites and ground-based all-sky imagers

Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice

Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary lymphoid organs (ATLOs). Aging-associated aorta B cell-related transcriptomes were identified and transcript atlases revealed highly territorialized B cell responses in ATLOs versus atherosclerotic lesions: ATLOs showed upregulation of bona fide B cell genes including Cd19, Ms4a1 (Cd20), Cd79a/b, and Ighm though intima plaques preferentially expressed molecules involved in non-B effector responses towards B cell-derived mediators, i.e. Fcgr3 (Cd16), Fcer1g (Cd23), and the C1q family. ATLOs promoted B cell recruitment. ATLO B-2 B cells included naïve, transitional, follicular, germinal center, switched IgG1+, IgA+, and IgE+ memory cells, plasmablasts, and long-lived plasma cells (PCs). ATLOs recruited large numbers of B-1 cells whose subtypes were skewed towards IL-10+ B-1b cells versus IL-10- B-1a cells. ATLO B-1 cells and PCs constitutively produced IgM and IgG and a fraction of PCs expressed IL-10. Moreover, ApoE-/- mice showed increased germinal center B cells in renal lymph nodes, IgM-producing PCs in the bone marrow, and higher IgM and anti-MDA-LDL IgG serum titers. Conclusions: ATLOs orchestrate dichotomic, territorialized, and multi-layered B cell responses in the diseased aorta; germinal center reactions indicate generation of autoimmune B cells within the diseased arterial wall during aging